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Distinctive features are 1 poor judgement; 2 irritability; 3 poor impulse control; 4 lack of insight; 5 hyper- or hypo-sexuality; 6 inability to learn from experience. A neuropathologist must be a good neuroanatomist, and it is essential to describe the location "distribution" accurately in making clinico-pathologic correlations. The immunoglobulin genes of Reed—Sternberg cells are hypermutated to the same extent as germinal-center B cells. The focus is on rehabilitating, educating, finding resources, and helping people manage in spite of disabilities. The cells expressed EBNA-2, which is characteristic of the growth program. Central to the discussion in this article is the idea that EBV uses a strategy of transforming latently infected B cells into proliferating blasts because only in this way can the virus convert these cells into long-lived memory cells and thereby make the cells nonpathogenic. Brain disease is common.

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A generic term for all the following. Then the memory cells exit the cell cycle and enter the peripheral circulation. But in the vast majority of cases, the etiology is never found.

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